Much like the multiplayer in the previous Dr.

Several modes new to this series are added, including a Multiplayer mode where four players can compete with each other. If more than one virus is eliminated in a single move, every subsequent virus is twice the score of the previous, where the rewarded score is maxed out at the sixth virus, meaning that any virus after the sixth is scored the same (3200, 6400, and 9600 for the respective speeds). The base score for Low, Med, and Hi respectively are 100, 200, and 300. The score obtained is based on the Speed, which also determines the speed in which vitamin capsules drop. There are three types of Viruses - the Red Virus (Fever), the Blue Virus (Chill) and the Yellow Virus (Weird), with a vitamin color designed to defeat them. Vitamin capsules are thrown into a bottle full of viruses, and the goal is to line up a minimum of four of a color combination of viruses and vitamins to make them disappear.

Mario 64 has the same gameplay as its predecessors for the most part.

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